1) Design of scientific and medical illustrations 2) Cover images for all scientific magazines 3)

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Bhubaneswar, Khorda, Odisha, India
am Krishn Verma, Associate Scientific Visualizer in KIIT-TBI, Bhuneshwar, Odisha, former worked as Senior Character and Environment Artist. I had been in the Gaming industry for almost 15 years now. I had worked as Assistant Professor /E-Coach in Lovely Professional University and also worked in CYMPL (Medha edutainment Pvt. Ltd. (a division of RSB Industries Corporate Group Inc.) focused towards bringing these positive values in the field of Game Entertainment and making game in all mobile platform, working with the company gives me a chance to acquire, learned and research wide. knowledge of Indian culture value and tried myself to imbibe my 3d game art knowledge into Indian mobile. game industry such Krishna Run, Maya 3-Fold reality, Dice math, Astra Slash, Rise of Defender, Zoono etc and many others and developed pipeline for studio with their logo design.

Monday, October 18, 2021

Portfolio

 https://doi.org/10.1016/j.vaccine.2021.09.025.




The schematic representation of the immunoinformatics guided design of the multi-epitope vaccine construct against K.pneumoniae.

The structural arrangement of B and T-cell epitopes along with linkers and adjuvant for the final multi-epitope vaccine construct.



Secondary structure prediction of the final multi-epitope vaccine construct by using PSIPRED tool.


Restriction cloning of final multi-epitope vaccine by using pET28a (+) expression vector in the in silico space. Black circle indicates the vector, and the magenta part is the place where the vaccine is inserted. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Restriction cloning of final multi-epitope vaccine by using pET28a (+) expression vector in the in silico space. Black circle indicates the vector, and the magenta part is the place where the vaccine is inserted. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)



Analysis of RMSD, and RMSF plots of native and mutant vaccine-TLR2 complex at 100 ns (a) Time evolution backbone RMSD plot of the native complex. (b) RMSF plot of the native structure. (c) RMSD plot of the mutant complex (d) RMSF plot of the mutant structure.

Molecular interaction of multi-epitope vaccine construct docked with TLR2.

The conformational B-lymphocyte epitopes present in the vaccine. The yellow spheres showing epitopes containing (a) 29 residues

Disulphide engineering of the vaccine protein. Residue pairs showed in red (CYS107, VAL248) and green (CYS30, ALA201) spheres were mutated to Cysteine residues to form disulphide bridge between them. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)



Several structure validation tools results confirmed the modeled multi-epitope vaccine structure to be reliable and accurate.

Homology modeling of the three-dimensional structure of the final multiepitope vaccine construct. The green structure represents the epitopic protein antigen while the blue represents the adjuvant CTB (P01556) protein. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.

https://doi.org/10.3390/vaccines9080812

The comparative illustration of traditional vaccine production and CoV vaccine development. The reasons for focusing on each of these technologies for COVID-19 include their rapid expansion, scale, and manufacturing fit, and small dose size, which are all highly desirable features for a rapid pandemic response.


Computational approaches and online databases. The freely accessible integrated platforms can also be used as tools for coronavirus identification, analytical genomics evaluation, vaccine and drug discovery





Types of Vaccine development approaches and platforms. They differ in whether they use the entire virus or bacterium, only the germs parts that activate the immune system or only the genetic material that instruction for making specific proteins rather than the entire virus.









https://doi.org/10.1080/14760584.2022.2021882








Workflow employed for the vaccine design.



Schematic representation of the methodology for the development of multi-epitope vaccine against pneumonia fever.


Developed multi-epitope vaccine structure validation results confirmed the model to be reliable and accurate.







Developed multi-epitope vaccine structure validation results confirmed the model to be reliable and accurate.

Secondary structure prediction of the final multi-epitope vaccine construct by using PSIPRED tool.

The structural arrangement of B and T-cell epitopes along with linkers and adjuvant for the final multi-epitope vaccine construct


Molecular interaction between the predicted T-cell epitopes and their respective HLA binding alleles
.




 Our services

1) Graphical abstract for scientific and medical illustrations

2) Cover images for all scientific magazines

3) Scientific animation and infographics

4) Design of logos, brochures and banners

5) Web design

Who we are

We are a group of scientists and graphic designers with PhDs from renowned colleges in the India. We combine PhD-level scientific knowledge with professional arts design to create visually appealing scientific pictures for articles, proposals, books, and other publications. We provide the most reasonable rates among the scientific illustrators while maintaining the greatest degree of quality in our work. 

Please shoot us an email to begin the dialogue if you have a design project in mind.